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参考文献1）Mori E, Yoneda Y, Tabuchi M, et al：Intravenous recombinanttissue plasminogen activator in acute carotid artery territorystroke. Neurology 42：976-982, 19922）Yamaguchi T, Hayamawa T, Kikuc....

参考文献1）Mori E, Yoneda Y, Tabuchi M, et al：Intravenous recombinanttissue plasminogen activator in acute carotid artery territorystroke. Neurology 42：976-982, 19922）Yamaguchi T, Hayamawa T, Kikuchi H；for the JapaneseThrombolysis Study Group：Intravenous tissue plasminogenactivator ameliorates the outcome of hyperacute embolicstroke. Cerebrovasc Dis 3：269 -272, 19933）The National Institutes of Neurological Disorders and Strokert -PA Stroke Study Group：Tissue plasminogen activatorfor acute ischemic stroke. N Engl J Med 333：1581-1587,19954）Yamaguchi T, Mori E, Minematsu K, et al；Japan AlteplaseClinical Trial（J -ACT）Group：Alteplase at 0.6 mg/kg foracute ischemic stroke within 3 hours of onset. JapanAlteplase Clinical Trial（J -ACT）. Stroke 37：1810 -1815,20065）Mori E, Minematsu K, Nakagawara J, et al；Japan AlteplaseClinical TrialⅡGroup：Effects of 0.6 mg/kg intravenousalteplase on vascular and clinical outcomes in middle cerebralartery occlusion. Japan Alteplase Clinical TrialⅡ（J-ACTⅡ）. Stroke 41：461-465, 20106）Nakagawara J, Minematsu K, Okada Y, et al；J -MARSInvestigators：Thrombolysis with 0.6 mg/kg intravenousalteplase for acute ischemic stroke in routine clinical practice.The Japan post -Marketing Alteplase Registration Study（J -MARS）. Stroke 41：1984-1989, 20107）中川原譲二：rt -PA静注療法の臨床的転帰に及ぼす患者背景因子の影響．脳卒中30：782-785, 20088）Hirano T, Sasaki M, Mori E, et al；Japan Alteplase ClinicalTrialⅡGroup：Residual vessel length on magnetic resonanceangiography identifies poor responders to alteplase inacute middle cerebral artery occlusion patients：Exploratoryanalysis of the Japan Alteplase Clinical TrialⅡ. Stroke 41：2828-2833, 20109）岡田靖,峰松一夫,小川彰ほか：rt-PA（アルテプラーゼ）静注療法の承認後4年間の全国における実施状況調査～地域格差の克服に向けて～.脳卒中32：365-372, 201010）Hacke W, Kaste M, Bluhmki E, et al；ECASS Investigators：Thrombolysis with alteplase 3 to 4.5 hours after acute ischemicstroke. N Engl J Med 359：1317-1329, 200811）Sandercock P, Wardlaw JM, Lindley RI, et al；IST-3 collaborativegroup：The benefits and harms of intravenousthrombolysis with recombinant tissue plasminogen activatorwithin 6 h of acute ischaemic stroke（the third internationalstroke trial［IST-3］）：a randomized controlled trial. Lancet379：2352 -2363, 201212）Wardlaw JM, Murray V, Berge E, et al：Recombinant tissueplasminogen activator for acute ischaemic stroke：an updatedsystematic review and meta -analysis. Lancet 379：2364 -2372, 201213）Alexandrov AV, Molina CA, Grotta JC, et al；CLOTBUSTInvestigators：Ultrasound -enhanced systemic thrombolysisfor acute ischemic stroke. N Engl J Med 351：2170-2178,200414）Eggers J, Konig IR, Koch B, et al：Sonothrombolysis withtranscranial color -coded sonography and recombinant tissue-type plasminogen activator in acute middle cerebralartery main stem occlusion：results from a randomizedstudy. Stroke 39：1470 -1475, 200815）Molina CA, Ribo M, Rubiera M, et al：Microbubble administrationaccelerates clot lysis during continuous 2 -MHz ultrasoundmonitoring in stroke patients treated with intravenoustissue plasminogen activator. Stroke 37：425-429, 200616）Daffertshofer M, Gass A, Ringleb P, et al：Transcranial low -frequency ultrasound -mediated thrombolysis in brain ischemiaincreased risk of hemorrhage with combined ultrasoundand tissue plasminogen activator. Results of a phaseⅡclinical trial. Stroke 36：1441-1446, 200517）古幡博：経頭蓋超音波血栓溶解療法.臨床神経49：804 -806,200918）Hacke W, Furlan AJ, Al -Rawi Y, et al：Intravenous desmoteplasein patients with acute ischemic stroke selected byMRI perfusion-diffusion weighted imaging or perfusion CT（DIAS -2）：a prospective, randomized, double -blind, placebo-controlledstudy. Lancet Neurol 8：141-150, 200919）Parsons M, Spratt N, Bivard A, et al：A randomized trial oftenecteplase versus alteplase for acute ischemic stroke. NEngl J Med 366：1099 -1107, 201220）Khatri P, Hill MD, Palesh YY, et al；Interventional Managementof StrokeⅢInvestigators：Methodology of the InterventionalManagement of StrokeⅢTrial. Int J Stroke 3：130 -137, 200812Current Therapy 2012 Vol.30 No.111112